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TER
0.40% p.a.
Distribution policy
Accumulating
Replication
Physical
Fund size
EUR 1,329 m
Inception Date
8 September 2016
Holdings
200
Overview
Description
The iShares Healthcare Innovation UCITS ETF seeks to track the iSTOXX® FactSet Breakthrough Healthcare index. The iSTOXX® FactSet Breakthrough Healthcare index tracks companies across the world that are focused on innovation within global healthcare services, across both developed and emerging markets.
Documents
Chart
Basics
Data
| Index | iSTOXX® FactSet Breakthrough Healthcare |
| Investment focus | Equity, World, Health Care, Social/Environmental |
| Fund size | EUR 1,329 m |
| Total expense ratio | 0.40% p.a. |
| Replication | Physical (Optimized sampling) |
| Legal structure | ETF |
| Investment approach | Long-only |
| Sustainability | Yes |
| Fund currency | USD |
| Currency risk | Currency unhedged |
| Volatility 1 year (in EUR) | 16.08% |
| Inception/ Listing Date | 8 September 2016 |
| Distribution policy | Accumulating |
| Distribution frequency | - |
| Fund domicile | Ireland |
| Fund Provider | iShares |
| Fund Structure | Open-ended Investment Company (OEIC) |
| UCITS compliance | Yes |
| Administrator | State Street Fund Services (Ireland) Limited |
| Investment Advisor | |
| Custodian Bank | State Street Custodial Services (Ireland) Limited |
| Revision Company | Deloitte |
| Fiscal Year End | 31 May |
| Swiss representative | BlackRock Asset Management Schweiz AG |
| Swiss paying agent | State Street Bank International GmbH, Munich, Zurich Branch |
| Germany | 30% tax rebate |
| Switzerland | ESTV Reporting |
| Austria | Tax Reporting Fund |
| UK | UK Reporting |
| Italy | 26.0% |
| Indextype | Total return index |
| Swap counterparty | - |
| Collateral manager | Bank of New York Mellon|Euroclear|JP Morgan|State Street Bank |
| Securities lending | Yes |
| Securities lending counterparty | Barclays Bank Plc|Barclays Capital Securities Ltd.|BNP Paribas Arbitrage SNC|BNP Paribas SA|Citigroup Global Markets Ltd|Citigroup Inc|Credit Suisse Securities (Europe) Ltd.|Deutsche Bank AG|Goldman Sachs International|HSBC Bank Plc|J.P. Morgan Securities Plc|JP Morgan Chase & Co|Macquarie Bank Limited|Merrill Lynch International|Morgan Stanley & Co. International Plc|Nomura International Plc|Skandinaviska Enskilda Banken AB|Societe Generale SA|The Bank of Nova Scotia|UBS AG |
Similar ETFs
This section provides you with information on other ETFs with a similar investment focus to the iShares Healthcare Innovation UCITS ETF.
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Holdings
Below you find information about the composition of the iShares Healthcare Innovation UCITS ETF.
Top 10 Holdings
Weight of top 10 holdings
out of 200
18.00%
| Moderna | 3.63% |
| Natera | 1.78% |
| IQVIA Holdings | 1.73% |
| Illumina, Inc. | 1.65% |
| Genmab A/S | 1.63% |
| Amgen, Inc. | 1.54% |
| Merck & Co., Inc. | 1.53% |
| Celltrion, Inc. | 1.51% |
| Guardant Health | 1.51% |
| Abbott Laboratories | 1.49% |
Sectors
| Healthcare | 99.59% |
| Non-Corporate | 0.81% |
| Business Services | 0.19% |
| Finance | 0.00% |
As of 31/08/2026
ETF Savings plan offers
Here you can find information about the savings plan availability of the ETF. You can use the table to compare all savings plan offers for the selected savings rate.
Select your savings amount:
| Broker | Rating | Execution fee | Account fee | |
|---|---|---|---|---|
 | 0.00 € | 0.00 € | View offer** | |
 | 0.00 € | 0.00 € | View offer* | |
 | 0.00 € | 0.00 € | View offer* | |
 | 0.00 € | 0.00 € | View offer* | |
 | 0.00 € | 0.00 € | View offer* |
Detailed comparison of all offers
Source: justETF Research; as of 10/2026. The offers are sorted in the following way: 1. Rating 2. Execution fee 3. Number of ETF savings plans. In addition to the fees charged by online brokers, additional costs may apply. The stated fees are thus exclusive of standard market spreads, commissions, product costs and third-party fees. Please note: No guarantee can be given for the completeness, correctness and accuracy of the content listed. The information on the online brokers' homepages is decisive. Investments in securities involve risks.
*Affiliate link
** Important note: We are part of the Scalable Group since 2021 and are a wholly owned subsidiary of Scalable AG. This means that we are economically connected, but operate with editorial independence. Conflicts of interest are avoided because brokers — including Scalable — are evaluated according to uniform, objective criteria. You can view these in our transparent rating system. Ultimately, it’s up to you to decide how and with whom you want to invest.
*Affiliate link
** Important note: We are part of the Scalable Group since 2021 and are a wholly owned subsidiary of Scalable AG. This means that we are economically connected, but operate with editorial independence. Conflicts of interest are avoided because brokers — including Scalable — are evaluated according to uniform, objective criteria. You can view these in our transparent rating system. Ultimately, it’s up to you to decide how and with whom you want to invest.
Order fees
Here you can find information about different brokers that allow you to trade ETFs. Select your preferred order volume to compare the fees charged by the respective brokers.
Order volume:
| Broker | Rating | Order fee | ETF savings plans | |
|---|---|---|---|---|
| | 0.00 € | 3646 | View offer** | |
 | 0.00 € | 2603 | View offer* | |
| | 0.95 € | 2530 | View offer* | |
 | 1.00 € | 2986 | View offer* | |
| | 0.00 € | 1868 | View offer* |
Detailed comparison of all offers
Source: justETF Research; as of 10/2026. The offers are sorted in the following way: 1. Rating 2. Order fee 3. Number of ETF savings plans. In addition to the fees charged by online brokers, additional costs may apply. The stated fees are thus exclusive of standard market spreads, commissions, product costs and third-party fees. Please note: No guarantee can be given for the completeness, correctness and accuracy of the content listed. The information on the online brokers' homepages is decisive. Investments in securities involve risks.
*Affiliate link
** Important note: We are part of the Scalable Group since 2021 and are a wholly owned subsidiary of Scalable AG. This means that we are economically connected, but operate with editorial independence. Conflicts of interest are avoided because brokers — including Scalable — are evaluated according to uniform, objective criteria. You can view these in our transparent rating system. Ultimately, it’s up to you to decide how and with whom you want to invest.
*Affiliate link
** Important note: We are part of the Scalable Group since 2021 and are a wholly owned subsidiary of Scalable AG. This means that we are economically connected, but operate with editorial independence. Conflicts of interest are avoided because brokers — including Scalable — are evaluated according to uniform, objective criteria. You can view these in our transparent rating system. Ultimately, it’s up to you to decide how and with whom you want to invest.
Performance
Returns overview
| YTD | +25.59% |
| 1 month | +8.21% |
| 3 months | +13.18% |
| 6 months | +29.13% |
| 1 year | +34.17% |
| 3 years | +55.41% |
| 5 years | +15.07% |
| Since inception (MAX) | +115.70% |
| 2025 | +4.79% |
| 2024 | +7.98% |
| 2023 | -1.46% |
| 2022 | -18.99% |
Monthly returns in a heat map
Risk
Risk metrics in this section:
- Volatility, annualised, measured for 1, 3 and 5 year periods. The annualised volatility reflects the degree of price fluctuations during a one year period. The higher the volatility, the more significantly the price of the asset (stock, ETF, etc.) has changed in the past. Assets with higher volatility are generally considered more risky. We calculate the volatility based on the data for the past 1, 3 and 5 years so that you can see if price fluctuations for the ETF became stronger or weaker over time.
- Return per risk for 1, 3 and 5 year periods. This is the annualised (i.e. converted to a one year period) past return divided by the past annualised volatility. The metric puts the historical return of an asset in relation to its historical risk and gives you a retrospective indication of the degree of price fluctuation you had to bear with in order to obtain the return. We calculate this parameter for 1, 3 and 5 year periods to display its evolution over time.
- Maximum drawdown for a period. This shows the worst possible loss an investor could have suffered during the respective period, by first buying and subsequently selling the asset at the least favourable prices. For example, if there was the following sequence of daily ETF prices: 10€, 5€, 12€, 20€, an investor would have suffered the worst loss by buying for 10€ and subsequently selling for 5€. Therefore in this case the maximum drawdown would be (5€ - 10€)/10€ = -50%.
Risk overview
| Volatility 1 year | 16.08% |
| Volatility 3 years | 15.88% |
| Volatility 5 years | 18.22% |
| Return per risk 1 year | 2.12 |
| Return per risk 3 years | 1.00 |
| Return per risk 5 years | 0.16 |
| Maximum drawdown 1 year | -11.90% |
| Maximum drawdown 3 years | -21.98% |
| Maximum drawdown 5 years | -35.62% |
| Maximum drawdown since inception | -38.72% |
Rolling 1 year volatility
Stock exchange
Listings
| Listing | Trade Currency | Ticker | Bloomberg / iNAV Bloomberg Code | Reuters RIC / iNAV Reuters | Market Maker |
|---|---|---|---|---|---|
| gettex | EUR | 2B78 | - - | - - | - |
| Stuttgart Stock Exchange | EUR | 2B78 | - - | - - | - |
| Bolsa Mexicana de Valores | MXN | - | HEALN MM | HEALN.MX | |
| Borsa Italiana | EUR | HEAL | HEAL IM INAVHEAE | HEAL.MI | |
| Euronext Amsterdam | EUR | HEAL | HEAL NA | ||
| London Stock Exchange | GBX | DRDR | DRDR LN | DRDR.L | |
| London Stock Exchange | USD | HEAL | HEAL LN INAVHEAU | HEAL.L 0O64INAV.DE | |
| London Stock Exchange | GBP | - | DRDR LN INAVHEAG | DRDR.L 0O62INAV.DE | |
| SIX Swiss Exchange | USD | HEAL | HEAL SE INAVHEAU | HEAL.S 0O64INAV.DE | |
| XETRA | EUR | 2B78 | 2B78 GY INAVHEAE | 2B78.DE 0O60INAV.DE |
Further information
Further ETFs with similar investment focus
| Fund name | Fund Size in m € (AuM) | TER p.a. | Distribution | Replication |
|---|---|---|---|---|
| VanEck Genomics and Healthcare Innovators UCITS ETF A | 22 | 0.35% p.a. | Accumulating | Full replication |
| Xtrackers MSCI Genomic Healthcare Innovation UCITS ETF 1C | 12 | 0.30% p.a. | Accumulating | Full replication |
Latest articles
Frequently asked questions
What is the name of 2B78?
The name of 2B78 is iShares Healthcare Innovation UCITS ETF.
What is the ticker of iShares Healthcare Innovation UCITS ETF?
The primary ticker of iShares Healthcare Innovation UCITS ETF is 2B78.
What is the ISIN of iShares Healthcare Innovation UCITS ETF?
The ISIN of iShares Healthcare Innovation UCITS ETF is IE00BYZK4776.
What are the costs of iShares Healthcare Innovation UCITS ETF?
The total expense ratio (TER) of iShares Healthcare Innovation UCITS ETF amounts to 0.40% p.a.. These costs are withdrawn continuously from the fund assets and already included in the performance of the ETF. You don't have to pay them separately. Please have a look at our article for more information about the cost of ETFs.
Is iShares Healthcare Innovation UCITS ETF paying dividends?
iShares Healthcare Innovation UCITS ETF is an accumulating ETF. This means that dividends are not distributed to investors. Instead, dividends are reinvested in the fund on the ex-date, which leads to an increase of the ETF's share price.
What's the fund size of iShares Healthcare Innovation UCITS ETF?
The fund size of iShares Healthcare Innovation UCITS ETF is 1,329m Euro. See the following article for more information about the size of ETFs.
— Data provided by Trackinsight, etfinfo, Xignite Inc., gettex, FactSet and justETF GmbH. Quotes are either real-time (gettex) or 15 minutes delayed stock exchange quotes or NAVs (daily published by the fund provider). By default, ETF returns include dividend payments (if applicable). There is no warranty for completeness, accuracy and correctness for the displayed information.