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The best Innovation ETFs

How to invest in innovative technologies using ETFs

0.18% p.a. - 0.89% p.a.
annual total expense ratio (TER) of innovation ETFs
19 Indices
on innovative technologies, which are tracked by ETFs
20 ETFs
on innovative technologies
 
The best indices for innovation ETFs

How do I invest in innovative technologies?

Gaining new insights through research and using these insights to develop and implement new technologies is part of the business model of many companies.

Many of these efforts, with particular economic impact and dissemination, are expected to be in the health sector. The same applies to digital technologies, whose effects will probably not result in evolution but in a complete transformation of value chains and sales processes. Index providers evaluate companies according to their ambitions for innovation and construct specific indices based on this information.

In this investment guide, you will find all ETFs that allow you to invest in innovative technologies. Currently, there are 20 ETFs available.
 

iSTOXX® FactSet Breakthrough Healthcare performance

1 month: 5.40%
1 year: 34.83%
3 years: 51.18%
5 years: -1.21%
 

Innovation ETFs in comparison

The most important factors at a glance

When choosing an innovation ETF one should consider several other factors in addition to the methodology of the underlying index and performance of an ETF. For better comparison, you will find a list of all innovation ETFs with details on size, cost, age, income, domicile and replication method ranked by fund size.

Compare all innovation ETFs in detail
Compare all innovation ETFs in a chart

Provider
ISIN		   Fund size
in m CHF		 TER
in %		 Use of profits Fund domicile Replication method
iShares Healthcare Innovation UCITS ETFIE00BYZK4776 1,221 0.40% p.a. Accumulating Ireland Optimized sampling
L&G Healthcare Technology & Innovation UCITS ETF USD AccIE00BK5BC677 292 0.49% p.a. Accumulating Ireland Full replication
ARK Innovation UCITS ETF USD AccumulatingIE000GA3D489 277 0.75% p.a. Accumulating Ireland Full replication
UBS Solactive China Technology UCITS ETF USD accLU2265794276 179 0.47% p.a. Accumulating Luxembourg Full replication
Amundi MSCI China Tech UCITS ETF EURLU1681043912 163 0.55% p.a. Accumulating Luxembourg Full replication
Invesco ChiNext 50 UCITS ETF AccIE000AWRDWI7 156 0.49% p.a. Accumulating Ireland Full replication
Invesco MSCI China Technology All Shares Stock Connect UCITS ETF AccIE00BM8QS095 120 0.49% p.a. Accumulating Ireland Full replication
ARK Genomic Revolution UCITS ETF USD AccumulatingIE000O5M6XO1 99 0.75% p.a. Accumulating Ireland Full replication
HANetf HAN-GINS Tech Megatrend Equal Weight UCITS ETFIE00BDDRF700 97 0.59% p.a. Accumulating Ireland Full replication
WisdomTree Megatrends UCITS ETF USDIE0000902GT6 54 0.50% p.a. Accumulating Ireland Full replication
Amundi MSCI China Tech UCITS ETF USDLU1681044050 31 0.55% p.a. Accumulating Luxembourg Full replication
UBS MSCI USA Tech 125 Universal UCITS ETF USD accIE0003B4BV34 26 0.18% p.a. Accumulating Ireland Full replication
L&G Pharma Breakthrough UCITS ETFIE00BF0H7608 23 0.49% p.a. Accumulating Ireland Full replication
VanEck Genomics and Healthcare Innovators UCITS ETF AIE000B9PQW54 20 0.35% p.a. Accumulating Ireland Full replication
Harbor Health Care UCITS ETF AccumulatingIE00BJQTJ848 12 0.89% p.a. Accumulating Ireland Full replication
AB Global Disruptors Portfolio UCITS ETF USD AccLU3322522163 5 0.78% p.a. Accumulating Luxembourg Full replication
WisdomTree Tech Megatrends UCITS ETF USD AccIE0007Z28IJ7 3 0.50% p.a. Accumulating Ireland Optimized sampling
Janus Henderson US Transformational Growth High Conviction Equity UCITS ETF USD Acc.IE0009ZTL4B5 3 0.49% p.a. Accumulating Ireland Full replication
UBS Solactive China Technology UCITS ETF hCHF accLU2265794789 2 0.50% p.a. Accumulating Luxembourg Full replication
BIT Global Technology Leaders UCITS ETFDE000A4231H9 1 0.46% p.a. Accumulating Germany Full replication

Source: justETF.com; As of 14/10/2026

 

Find the best Innovation ETF

Return comparison of all innovation ETFs

The table shows the returns of all innovation ETFs in comparison. All return figures are including dividends as of month end. Besides the return the reference date on which you conduct the comparison is important. In order to find the best ETFs, you can also perform a chart comparison.

ETF   1 month
in %		 3 months
in %		 6 months
in %		 1 year
in %		 3 years
in %
ARK Genomic Revolution UCITS ETF USD Accumulating 17.67% 30.89% 124.33% 103.15% -
L&G Healthcare Technology & Innovation UCITS ETF USD Acc 7.72% 22.26% 45.45% 51.86% 62.54%
VanEck Genomics and Healthcare Innovators UCITS ETF A 10.39% 29.70% 53.35% 39.59% 41.67%
iShares Healthcare Innovation UCITS ETF 5.84% 16.60% 34.42% 38.53% 47.56%
UBS MSCI USA Tech 125 Universal UCITS ETF USD acc 6.60% 9.66% 38.69% 24.15% -
L&G Pharma Breakthrough UCITS ETF -1.44% 1.99% 18.33% 22.20% 32.01%
ARK Innovation UCITS ETF USD Accumulating 10.48% 15.06% 55.12% 20.90% -
WisdomTree Megatrends UCITS ETF USD 2.25% -5.28% 16.71% 16.35% -
Harbor Health Care UCITS ETF Accumulating 0.88% 1.48% 22.36% 15.54% 14.00%
Janus Henderson US Transformational Growth High Conviction Equity UCITS ETF USD Acc. 3.16% -1.61% 36.35% 15.04% -
HANetf HAN-GINS Tech Megatrend Equal Weight UCITS ETF 5.47% 1.67% 34.76% 11.04% 71.55%
Invesco ChiNext 50 UCITS ETF Acc -4.65% -26.16% 5.13% 9.26% -
Amundi MSCI China Tech UCITS ETF EUR -4.61% -6.56% -5.11% -17.85% 6.07%
Amundi MSCI China Tech UCITS ETF USD -4.39% -6.85% -4.93% -17.88% 6.17%
Invesco MSCI China Technology All Shares Stock Connect UCITS ETF Acc -4.94% -9.07% -2.80% -19.51% 18.48%
UBS Solactive China Technology UCITS ETF USD acc -3.40% -3.73% -6.12% -28.37% 10.51%
AB Global Disruptors Portfolio UCITS ETF USD Acc 6.08% -7.56% - - -
BIT Global Technology Leaders UCITS ETF 0.70% - - - -
UBS Solactive China Technology UCITS ETF hCHF acc -7.16% -7.85% - - -
WisdomTree Tech Megatrends UCITS ETF USD Acc 7.17% -2.12% 35.12% - -
ETF   2026
in %		 2025
in %		 2024
in %		 2023
in %		 2022
in %
ARK Genomic Revolution UCITS ETF USD Accumulating 94.21% 8.04% - - -
VanEck Genomics and Healthcare Innovators UCITS ETF A 32.74% 2.97% 2.57% -13.58% -
L&G Healthcare Technology & Innovation UCITS ETF USD Acc 30.72% 8.79% 11.33% -11.89% -32.48%
ARK Innovation UCITS ETF USD Accumulating 27.96% 21.33% - - -
iShares Healthcare Innovation UCITS ETF 26.36% 3.63% 9.73% -7.25% -22.83%
UBS MSCI USA Tech 125 Universal UCITS ETF USD acc 21.54% 5.56% - - -
HANetf HAN-GINS Tech Megatrend Equal Weight UCITS ETF 19.19% 4.19% 24.48% 32.25% -44.15%
Janus Henderson US Transformational Growth High Conviction Equity UCITS ETF USD Acc. 15.86% - - - -
WisdomTree Megatrends UCITS ETF USD 14.94% 14.05% 11.76% - -
L&G Pharma Breakthrough UCITS ETF 14.27% 19.69% 2.96% -18.55% -6.18%
Harbor Health Care UCITS ETF Accumulating 8.40% 4.82% -1.95% -7.81% -29.07%
Invesco ChiNext 50 UCITS ETF Acc 7.22% 50.85% - - -
Amundi MSCI China Tech UCITS ETF USD -9.45% 21.28% 10.16% -19.36% -7.80%
Invesco MSCI China Technology All Shares Stock Connect UCITS ETF Acc -9.84% 15.65% 30.11% -26.09% -29.88%
Amundi MSCI China Tech UCITS ETF EUR -9.96% 20.93% 10.49% -19.29% -7.48%
UBS Solactive China Technology UCITS ETF USD acc -15.35% 23.69% 19.91% -18.73% -31.16%
AB Global Disruptors Portfolio UCITS ETF USD Acc - - - - -
BIT Global Technology Leaders UCITS ETF - - - - -
UBS Solactive China Technology UCITS ETF hCHF acc - - - - -
WisdomTree Tech Megatrends UCITS ETF USD Acc - - - - -

Source: justETF.com; As of 30/09/2026; Calculations in CHF including dividends