The best Biotech ETFs

How to invest in biotech using ETFs

0.35% p.a. - 0.50% p.a.
annual total expense ratio (TER) of biotech ETFs
on biotech, which are tracked by ETFs
on biotech
The best indices for biotech ETFs

How do I invest in biotech stocks?

The main objective of biotech companies is to develop new or more efficient methods of diagnosis and ways of producing chemical compounds. For this purpose, knowledge from various fields of natural science is employed, mostly in combination with the latest digital technology. The outcomes are then used in medicine, agriculture or industry.

Biotech indices track companies that are active in these fields as well as firms that provide the relevant infrastructure.

In this investment guide, you will find all the ETFs that give you exposure to biotech stocks. Currently, there is 2 index available tracked by 3 ETFs.

Nasdaq Biotechnology performance

1 month: -0.34%
1 year: 16.97%
3 years: 50.60%
5 years: 53.61%

Biotech ETFs in comparison

The most important factors at a glance

When choosing a biotech ETF one should consider several other factors in addition to the methodology of the underlying index and performance of an ETF. For better comparison, you will find a list of all biotech ETFs with details on size, cost, age, income, domicile and replication method ranked by fund size.

Compare all biotech ETFs in detail
Compare all biotech ETFs in a chart

  Fund size
in m EUR
in %
Use of profits Fund domicile Replication method
Invesco Nasdaq Biotech UCITS ETFIE00BQ70R696 622 0.40% p.a. Accumulating Ireland Unfunded swap
iShares Nasdaq US Biotechnology UCITS ETFIE00BYXG2H39 441 0.35% p.a. Accumulating Ireland Optimized sampling
Global X Genomics & Biotechnology UCITS ETFIE00BM8R0N95 - 0.50% p.a. Accumulating Ireland Full replication

Source:; As of 27.11.21


Return comparison of all biotech ETFs

The table shows the returns of all biotech ETFs in comparison. All return figures are including dividends as of month end. Besides the return the reference date on which you conduct the comparison is important. In order to find the best ETFs, you can also perform a chart comparison.

ETF   1 month
in %
3 months
in %
6 months
in %
1 year
in %
3 years
in %
iShares Nasdaq US Biotechnology UCITS ETF -2.54% -0.81% 6.42% 22.60% 48.79%
Invesco Nasdaq Biotech UCITS ETF -2.47% -0.79% 6.52% 22.59% 48.89%
Global X Genomics & Biotechnology UCITS ETF - - - - -
ETF   2021
in %
in %
in %
in %
in %
Invesco Nasdaq Biotech UCITS ETF 10.66% 15.26% 27.01% -4.92% 6.48%
iShares Nasdaq US Biotechnology UCITS ETF 10.05% 15.18% 26.91% -4.77% -
Global X Genomics & Biotechnology UCITS ETF - - - - -

Source:; As of 31.10.21; Calculations in EUR including dividends